Cal. Code Regs. Tit. 22, § 69402.5 - Reproductive Toxicity

(a) The reproductive toxicity hazard trait is defined as the occurrence of adverse effects on the reproductive system or reproductive function of females or males following exposure to a chemical substance.

(b) Toxicological endpoints for reproductive toxicity include, but are not limited to: adverse alterations to the female or male reproductive organs, the related endocrine system, or pregnancy outcomes; adverse effects on onset of puberty, gamete production and transport, reproductive cycle normality, sexual behavior, fertility, gestation, parturition, or lactation; developmental toxicity, premature reproductive senescence, or other modifications that compromise the integrity of the reproductive system or reproductive function in animals or humans.

(c) Other relevant data include but are not limited to: data on endocrine disruption, genotoxicity, in vitro measures of the capacity of a chemical to damage the function or structure of germ cells such as sperm or oocytes or cells critical for reproductive function, such as Sertoli and Leydig cells in males; structural or mechanistic similarity to other substances that are toxic to reproductive systems.

Notes

Cal. Code Regs. Tit. 22, § 69402.5

1. New section filed 12-20-2011; operative 1-29-2012 (Register 2011, No. 51).

Note: Authority cited: Sections 25256.1 and 59012, Health and Safety Code. Reference: Sections 25256.1 and 59012, Health and Safety Code.

1. New section filed 12-20-2011; operative 1-29-2012 (Register 2011, No. 51).