Cal. Code Regs. Tit. 22, § 69403.16 - Respiratory Toxicity

(a) The respiratory toxicity hazard trait is defined as the occurrence of adverse effects on the structure or function of the respiratory tract following exposure to a chemical substance, including respiratory tract injury or decreased ability of the lungs to function in gas exchange.

(b) Toxicological endpoints for respiratory toxicity include, but are not limited to those indicating: respiratory irritation; pathological changes to the airway or other lung structures; inflammation; fibrosis; hypersensitivity pneumonitis; airways hyperresponsiveness; altered lung function; asthma; airways remodeling; increased respiratory infections; altered composition of bronchoalveolar lavage fluid.

(c) Other relevant data include but are not limited to: in vitro evidence for respiratory toxicity; particle size distribution inclusive of respirable particles; respirable fibers; long half-life in the lung; chemical reactivity; redox potential; structural or mechanistic similarity to other chemical substances that are toxic to the respiratory system.

Notes

Cal. Code Regs. Tit. 22, § 69403.16

1. New section filed 12-20-2011; operative 1-29-2012 (Register 2011, No. 51).

Note: Authority cited: Sections 25256.1 and 59012, Health and Safety Code. Reference: Sections 25256.1 and 59012, Health and Safety Code.

1. New section filed 12-20-2011; operative 1-29-2012 (Register 2011, No. 51).