Cal. Code Regs. Tit. 22, § 69404.10 - Evidence for Environmental Hazard Traits
(a) For a given chemical substance, either of
the following constitutes strong evidence of any of the hazard traits
identified in this article:
(1) An
authoritative organization identifies or otherwise indicates that the chemical
substance has the hazard trait by:
(A)
Concluding based on well-conducted scientific studies that the chemical has the
hazard trait.
(B) Using the hazard
trait in a hazard identification, dose-response assessment, risk assessment, or
other scientific evaluation.
(C)
Including the chemical substance on a list of substances identified as having,
or being regulated based on, the hazard trait.
(2) The available data from well-conducted
scientific studies show that exposure to the chemical substance induces an
environmental endpoint or endpoints for the hazard trait. Studies include, but
are not limited to, standard aquatic and terrestrial toxicity testing as well
as research-based investigations.
(b) For a given chemical substance, each of
the following constitutes suggestive evidence of any of the hazard traits
identified in this article:
(1) An
authoritative organization identifies or discusses the chemical substance as
possibly having the hazard trait.
(2) The available data from well-conducted
scientific studies suggest exposure to the chemical substance induces a
toxicological endpoint or endpoints for the hazard trait. Studies can be, but
are not limited to, standard aquatic and terrestrial toxicity tests or a
research-based investigation.
(3)
Mechanistic evidence that is suggestive of the hazard trait from cell-based,
tissue-based or whole organism-based assays showing perturbations of known
physiological, biochemical or other pathways involved in causing the hazard
trait.
(4) Strong indications of
the hazard trait from structure activity relationships, including, but not
limited to, those from Quantitative Structure Activity Relationship
programs.
Notes
State regulations are updated quarterly; we currently have two versions available. Below is a comparison between our most recent version and the prior quarterly release. More comparison features will be added as we have more versions to compare.
No prior version found.