20 CSR 2220-6.040 - Administration by Medical Prescription Order

PURPOSE: This rule establishes procedures for pharmacists to administer medication pursuant to a medical prescription order.

(1) A pharmacist who complies with the provisions of this rule may administer drugs and devices pursuant to a medical prescription order, including vaccines.
(2) Except as otherwise provided by law, a pharmacist may not delegate medication administration to another person, except to an intern pharmacist or qualified pharmacy technician who has met the qualifications under subsections (3)(B)-(E) and is working under the direct supervision of a pharmacist who has met the qualifications to administer drugs pursuant to a medical order.
(A) For purposes of this rule, a "qualified pharmacy technician" is defined as a currently registered Missouri pharmacy technician who-
1. Holds an active pharmacy technician certification issued by a certification entity accredited by the National Commission for Certifying Agencies;
2. Has an initial and, if applicable, annual documented assessment of competency in medication administration; and
3. Has assisted in the practice of pharmacy as a registered/ licensed pharmacy technician in the state of Missouri or another U.S. state or territory for a minimum of one (1) year.
(B) Proof of an intern's or qualified pharmacy technician's compliance with subsections (3)(B)-(E) must be maintained by both the supervising pharmacist and the intern pharmacist/ qualified pharmacy technician for a minimum of two (2) years.
(3) Pharmacist Qualifications. A pharmacist who is administering drugs pursuant to a medical prescription order must first file a Notification of Intent to administer drugs by medical prescription order with the board. To file a Notification of Intent, a pharmacist must-
(A) Hold a current Missouri pharmacist license;
(B) Hold a current healthcare provider level cardiopulmonary resuscitation (CPR) certification or Basic Life Support certification issued by the American Heart Association, the American Red Cross, or an equivalent organization. The certificate program must have included an in-person skills assessment;
(C) Have successfully completed a certificate program in medication administration and emergency procedures accredited by the Accreditation Council for Pharmacy Education (ACPE), provided by an ACPE or regionally accredited pharmacy or medical school/college or approved by the Board of Pharmacy. The required training program must provide instruction in-
1. Administration techniques, including hands-on training in routes of administration;
2. Drug storage and handling;
3. Informed consent requirements;
4. Pre- and post- administration assessment and counseling;
5. Biohazard waste disposal; and
6. Identifying and treating adverse reactions, including anaphylactic reactions and needle sticks;
(D) If a pharmacist wishes to administer drugs by a route of administration not included in the original certification program, the pharmacist must first be trained in the techniques of that route of administration by a licensed health care practitioner who is authorized to administer medication. Documentation of the required training and training date(s) must be maintained at the pharmacy and available to the board on request; and
(E) Proof of compliance with this section must be maintained for a minimum of two (2) years.
(4) General Requirements.
(A) Medication must be administered in compliance with all applicable state and federal laws, including applicable Vaccine Information Statements and informed consent requirements. Except as otherwise authorized by law, vaccines must also be administered in accordance with treatment guidelines established by the Centers for Disease Control and Prevention (CDC) or in accordance with manufacturer's guidelines.
(B) Pharmacists must have a current and accurate written policy and procedure manual covering all aspects of administering drugs by medical prescription order, including:
1. Drug administration procedures;
2. Authorized routes of administration;
3. Drug storage;
4. Pre- and post- administration assessment and counseling;
5. Biohazard waste disposal and disposal of used/contaminated supplies;
6. Identifying and handling acute adverse events or immunization reactions, including anaphylactic reactions; and
7. Recordkeeping and notification procedures and requirements.
(C) Drugs must be stored within the manufacturer's labeled requirements, including when administering outside of a pharmacy. Vaccines must be stored in accordance with CDC guidelines at all times.
(D) Patients must be asked to remain in the pharmacy a safe amount of time after administering a vaccine to observe any adverse reactions, as required by section 338.010, RSMo.
(5) Requirements of Medical Prescription Order for Administration. At a minimum, the medical prescription order from a licensed prescriber must include:
(A) The name of the licensed prescriber issuing or authorizing the order;
(B) The name of the patient to receive the drug;
(C) The name of the drug and dose to be administered;
(D) The route of administration;
(E) The date of the original order; and
(F) The date or schedule, if any, of each subsequent administration.
(6) Record Keeping.
(A) Pharmacists administering or supervising administration of medication pursuant to this rule shall ensure the following records are manually or electronically maintained separate from the prescription files of a pharmacy for each administration:
1. The name, address, and date of birth of the patient;
2. The date, route, and anatomic site of the administration;
3. The medication name and dose. For vaccines and biologics, the manufacturer, expiration date, and lot number must also be documented and recorded;
4. For vaccines, the name and address of the patient's primary health care provider, as identified by the patient or an indication that a primary health care provider was not provided;
5. The identity of the administering pharmacist, or if applicable, the administering intern pharmacist or qualified pharmacy technician and his/her supervising pharmacist; and
6. If applicable, the nature of an adverse reaction and who was notified.
(B) All records required by this regulation must be kept by the pharmacist for two (2) years from the date of such record. Except as otherwise required by section (3), records must be kept at the pharmacy where the prescription order is maintained. If not administered on behalf of a pharmacy, records not maintained at a pharmacy may be securely stored at a location designated by the pharmacist. Records maintained at a pharmacy must be produced immediately or within two (2) hours of a request from the board or the board's authorized designee. Records not maintained at a pharmacy must be produced within three (3) business days of a board request.
(7) Notification Requirements. Pharmacists administering or supervising administration of medication under this rule, shall ensure-
(A) For vaccines, a pharmacist shall inform the patient that the administration of the vaccine will be entered into the ShowMeVax system, as administered by the Department of Health and Senior Services. The patient shall attest to the inclusion of such information in the system by signing a form provided by the pharmacist. Entry into ShowMeVax must occur within fourteen (14) days. If the patient indicates that he or she does not want such information entered into the ShowMeVax system, the pharmacist must provide a written report within fourteen (14) days of administration of a vaccine to the patient's primary health care provider, if provided by the patient, containing-
1. The identity of the patient;
2. The identity of the vaccine or vaccines administered;
3. The route of administration;
4. The anatomic site of the administration;
5. The dose administered; and
6. The date of administration;
(B) The prescriber is notified within twenty-four (24) hours after learning of an adverse event or reaction experienced by a patient following administration. Notification is mandatory and cannot be waived. Vaccine adverse events or reactions must also be reported to the Vaccine Adverse Event Reporting System (VAERS) or its successor, within thirty (30) days;
(C) Any notifications required by state and federal law are properly completed and documented; and
(D) Notifications required by this section may be made electronically or in writing or via a common electronic medication record that is accessible to and shared by both the physician and pharmacist. Documentation of the required notifications, including the notification date, must be maintained as required by subsection (6)(B) or electronically retrievable at the request of the board or the board's authorized designee.
(8) Notification of Intent Refiling. To continue administration, a Notification of Intent to administer drugs by medical prescription order must be refiled with the board biennially along with the pharmacist's Missouri pharmacist license. To refile, a pharmacist must meet the requirements of subsection (3)(B) above.
(9) A qualified pharmacy technician administering medication pursuant to this rule must be supervised by a Missouri-licensed pharmacist who is authorized to administer medication pursuant to this rule and who is physically present on-site when the medication is administered.

Notes

20 CSR 2220-6.040
AUTHORITY: section 338.280, RSMo 2016, and sections 338.010.1 and 338.140, RSMo Supp. 2020.* Emergency rule filed May 1, 2008, effective May 11, 2008, expired Feb. 18, 2009. Original rule filed May 1, 2008, effective Nov. 30, 2008. Amended: Filed Dec. 15, 2017, effective June 30, 2018. ** Emergency amendment filed Nov. 25, 2020, effective Dec. 11, 2020, expired June 8, 2021. Amended: Filed Nov. 25, 2020, effective May 30, 2021.
AUTHORITY: sections 338.140 and 338.280, RSMo 2000 and section 338.010.1, RSMo Supp. 2007.* Emergency rule filed May 1, 2008, effective May 11, 2008, expired Feb. 18, 2009. Original rule filed May 1, 2008, effective Nov. 30, 2008. Amended by Missouri Register May 15, 2018/Volume 43, Number 10, effective 7/2/2018 Amended by Missouri Register April 15, 2021/Volume 46, Number 08, effective 5/31/2021

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