Cal. Code Regs. Tit. 22, § 69404.8 - Wildlife Reproductive Impairment
(a) The wildlife reproductive impairment
hazard trait is defined as the occurrence of adverse effects on the
reproductive system or sexual function of wildlife, including aquatic and
terrestrial organisms, following exposure to a chemical substance that may
reduce reproductive capacity in the environment.
(b) Environmental endpoints for wildlife
reproductive impairment include, but are not limited to those indicating:
adverse changes in reproductive endocrine function, sexual maturation,
structure and function of reproductive organs, including intersex and imposex
organs, secondary sex characteristics, behavior related to reproduction such as
mating and parental care, vitellogenin production, fecundity, fertility, or
offspring sex ratio observed in the laboratory or in a wild population,
including aquatic and terrestrial species. Endpoints of toxicity described for
the toxicological hazard traits in Article 2 sections
69402.5 and
69403.3 of this Chapter are also
valid endpoints for wildlife reproductive impairment.
(c) Other relevant reproductive impairment
data include but are not limited to: mechanistic or structural similarity to
other chemical substances that impair wildlife reproduction; in
vitro evidence of exposure related perturbations of the
hypothalamic-pituitary-gonadal axis; agonism of the aryl hydrocarbon receptor;
binding or disruption of the function of the estrogen or androgen receptors;
toxicogenomic responses associated with reproductive impairment; other relevant
data as described for toxicological hazard traits in Article 2 section
69402.5 or Article 3 section
69403.3 of this Chapter;
associative data from field studies linking exposure to a chemical substance
with reductions in animal reproduction.
Notes
Note: Authority cited: Sections 25256.1 and 59012, Health and Safety Code. Reference: Sections 25256.1 and 59012, Health and Safety Code.
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